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Isis Kanevsky Mullarky |
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| Education | Assistant Professor | |
| Awards and Honors | Department of Dairy Science (0315) | |
| Professional Experience | 2050 Litton-Reaves Hall | |
| Research | Virginia Tech | |
| Publications | Blacksburg, VA 24061 | |
| Positions Available | Phone: (540) 231-2410 | |
| Mastitis and Immunology Lab | Fax: (540) 231-5014 | |
| Email: mullarky@vt.edu | ||
| BS | University of Vermont | 1996 |
| MS | University of Vermont | 1998 |
| Ph.D. | The Pennsylvania State University | 2003 |
| 1996 | Merck Award of Excellence | University of Vermont |
| 1998 | Teaching Assistant Award | University of Vermont |
| 1999 | Mr. and Mrs. E. Bosworth Grier Scholarship | Penn State University |
| 1999 | The American College of Veterinary Microbiology Awards | Conference Research Workers in Animal Disease |
| 2000 | The American Association of Veterinary Immunologists Award | Conference Research Workers in Animal Disease |
| 2002 | Alumni Association Dissertation Award | Penn State University |
| 2003 | NIH Institutional Training Grant | Trudeau Institute |
| 1994-1998 | Research Assistant with Dr. Woodrow Pankey | Quality Milk Research Laboratory, Burlington, Vermont |
| 1998-2004 | Research Assistant with Dr. Lorraine Sordillo | The Center for Mastitis Research, State College, Pennsylvania |
| 2003-2006 | Postdoctoral Research Associate with Dr. Stephen Smiley | The Trudeau Institute, Saranac Lake, New York |
| 2006-present | Assistant Professor | Department of Dairy Science, Virginia Tech, Blacksburg, Virginia |
Our current research focus is determining the role of coagulation in immunity. We hypothesize that the identification of the mechanisms regulating fibrin deposition during infection will provide new targets for both the prevention of dissemination and abscess formation during staphylococcal infections. Furthermore, the study of fibrin deposition during infection of the mammary gland may provide new insight into controlling pathogens at the acute stage of infection thereby preventing the establishment of chronic infection. For more details visit our labweb site: Mastitis and Immunology Lab
Mullarky IK, Szaba FM, Kummer LW, Wilhelm, LB, Parent MA, Johnson LL, Smiley ST. Interferon-gamma suppresses erythropoiesis via interleukin-15. Infection and Immunity. 2007 May;75(5):2630-3. PMID: 17307940
Mullarky IK, Szaba FM, Winchel, CG, Parent MA, Kummer LW, Mackman, N, Johnson LL, Smiley ST. In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis. J Thromb Haemost. 2006 Jul;4(7):1580-7. PMID: 16839357
Parent MA, Wilhelm LB, Kummer LW, Szaba FM, Mullarky IK, Smiley ST. Related Articles, Links Free in PMC Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun. 2006 Jun;74(6):3381-6. PMID: 16714568
Mullarky IK, Szaba FM, Berggren KN, Wilhelm LB, Parent MA, Kummer LW, Johnson LL, Smiley ST. Tumor necrosis factor-alpha (TNFα) and interferon-gamma (IFNγ), but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. Infection and Immunity. 2006 Feb;74(2):1181-8. PMID: 16428767
Trigona WL, Mullarky IK, Cao Y, Sordillo LM. Thioredoxin reductase regulates the induction of heme oxygenase-1 expression in aortic endothelial cells. Biochem J. 2006 Feb 15;394(Pt 1):207-16. PMID: 16209660
Parent MA, Berggren KN, , Kummer LW, Wilhelm LB, Szaba FM, Mullarky IK, Smiley ST. Cell-mediated protection against pulmonary Yersinia pestis infection. Infection and Immuninty. 2005 Nov;73(11):7304-10. PMID: 16239527
Mullarky IK, Szaba FM, Berggren KN, Parent MA, Kummer LW, Chen W, Johnson LL, Smiley ST. Infection-stimulated fibrin deposition controls hemorrhage and limits bacterial growth during listeriosis. Infection and Immunity. 2005 Jul;73(7):3888-95. PMID: 15972474
Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, and Mullarky IK. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins & Other Lipid Mediators. Prostaglandins Other Lipid Mediat. 2005 May;76(1-4):19-34. PMID: 15967159
Parent MA, Berggren KN, Mullarky IK, Szaba FM, Kummer LW, Adamovicz JJ, Smiley ST. Yersinia pestis V protein epitopes recognized by CD4 T cells. Infect Immun. 2005 Apr;73(4):2197-204. PMID: 15784563
Hancock WW, Szaba FM, Berggren KN, Parent MA, Mullarky IK, Pearl J, Cooper AM, Ely KH, Woodland DL, Kim IJ, Blackman MA, Johnson LL, Smiley ST. Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFNγ-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3005-10. PMID: 14976252
Weaver JA, Maddox JF, Cao YZ, Mullarky IK, Sordillo LM. Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells. Free Radic Biol Med. 2001 Feb 1;30(3):299-308. PMID: 11165876
Mullarky IK, Su C, Frieze N, Park YH, Sordillo LM. Staphylococcus aureus agr genotypes with enterotoxin production capabilities can resist neutrophil bactericidal activity. Infect Immun. 2001 Jan;69(1):45-51. PMID: 11119487
Su C, Kanevsky I, Jayarao BM, Sordillo LM. Phylogenetic relationships of Staphylococcus aureus from bovine mastitis based on coagulase gene polymorphism. Vet Microbiol. 2000 Jan;71(1-2):53-8. PMID: 10665533
Information on graduate studies can be obtained at the following websites: Department of Dairy Science and Virginia Tech.